OCTIVUS shows PCI outcomes improve with EAPCI-defined stent optimization, regardless of imaging modality. GADD45A deletion in mice led to cardiac fibrosis, inflammation, and hypertrophy, highlighting its protective role. Patients experienced a median 57.6-month delay from first symptoms to ATTR-CM diagnosis, study finds. MITT and safety data show acoramidis significantly lowers AFib-related events in transthyretin cardiac amyloidosis. Small study links adverse pregnancy outcomes with later development of pulmonary arterial hypertension. LuX-Valve offers a safe, effective option for severe TR patients at high surgical risk. Concomitant surgical ablation is currently underused in patients with atrial fibrillation. Black patients face higher amputation risk from PAD due to late CLTI care and limited access to revascularization. ESC 2025: Acoramidis may reduce AF/flutter burden in ATTR-CM, per new ATTRibute-CM trial analysis discussed by CardioNerds. PVR severity is linked to higher short-term mortality in HFrEF, highlighting its role in risk stratification. IMPLEMENT-HF raised heart failure quad therapy use from 4.7% to 44.6% at discharge and 0% to 44.8% at 30 days. Dr. Salman Allana shares key insights on how operator volume impacts retrograde CTO PCI success and outcomes. Routine health screenings may not reduce death risk, study finds—though early detection remains key. Experts call for better trials and teamwork to advance transcatheter valve treatment for heart failure-related valve disease. CTA-first screening before TAVR avoids invasive angiography in 53% of patients—without compromising outcomes. Delays in TAVI for acute decompensated aortic stenosis worsen outcomes. BMAL1-HIF2α link explains why AM heart attacks hit harder—new findings may lead to time-based cardioprotective therapies. AI-driven ECGs are transforming heart failure care—enabling early detection, cutting costs, and expanding access. First surgical removal of a Harmony valve due to endocarditis reveals complex challenges and implications. Pulsed field ablation proves safe, effective for persistent AF in ADVANTAGE AF trial, showing strong results and improved QoL